• There are mounting evidences supporting GM foods

  2018-11-08

  

  There are mounting evidences supporting GM foods are safe. In 2013, Nicolia et al. published a study which systematically reviewed a total of 1783 scientific papers on the safety of GM crops published from 2002 to October 2012. This report concluded that there is no evidence showing the use of GM cr

• Mouse nhpESC chimeras were also prepared using

  2018-11-08

  

  Mouse–nhpESC chimeras were also prepared using the mouse tetraploid complementation assay (Nagy, 2003). We electrofused mouse 2-cell embryos to produce 4N embryos and permitted these to develop to the expanded blastocyst stage before injecting them with GFP-expressing nhpESCs and performing embryo t

• It has been demonstrated that CCR is

  2018-11-08

  

  It has been demonstrated that CCR1 is biologically functional in BMSCs (Honczarenko et al., 2006). Here we have shown that CCL5 induces biological responses via CCR1, indicating that the CCL5/CCR1 axis is functional also in ADSCs. CCL5 may also bind to the CCR3 and CCR5 receptors; however, according

• Similar to our observation that Nanog

  2018-11-08

  

  Similar to our observation that Nanog−/− iPSCs could give rise to chimeric animals, Nanog null ESCs have been shown to contribute to the three germ layers (Chambers et al., 2007). However, in the case of ESC chimeras, Nanog−/− GFP+ meclofenoxate were not detected in the germline after E12.5. Becaus

• According to these roles in the developing cerebellum

  2018-11-08

  

  According to these roles in the developing cerebellum, we show that ASCL1 and NEUROG2 reprogram CerebAstro mostly into GABAergic iNs. Moreover, expression of calcium binding proteins reveals that ASCL1 and NEUROG2 lineage-reprogrammed CerebAstro iNs are distinct: while ASCL1 induces mostly CALBINDIN

• It is the first time to report the involvement

  2018-11-08

  

  It is the first time to report the involvement of miRNA-30c in enhancing sphere formation and neural differentiation. The relationships of miRNA-30c and osteodifferentiation and adipocyte differentiation have been discussed previously (Gao et al., 2011; Karbiener et al., 2011; Vimalraj and Selvamuru

• br Resource table br Resource

  2018-11-08

  

  Resource table Resource details The generation of the human iPSC line, Oex2054SV.4, was carried out using non-integrative Sendai viruses containing the reprogramming factors, OCT3/4, SOX2, CMYC, KLF4 (Takahashi et al., 2007). For this purpose, fibroblasts from a patient with an optic atrophy ‘

• A niche is defined as a microenvironment that

  2018-11-08

  

  A niche is defined as a microenvironment that maintains stem daidzin through growth factors, cell surface proteins and extracellular matrices (ECMs), and is identified in some organs such as the intestine, brain, skeletal muscle, skin and testis (Chen and Chuong, 2012; Gattazzo et al., 2014; Tanimu

• The four cell lines present

  2018-11-08

  

  The four cell lines present the typical morphology of pluripotent stem cells, growing in compact colonies, with tightly packed heme oxygenase (Fig. 1B). They express the pluripotency markers SSEA4, SSEA3, TRA-1-81, TRA-1-60 and OCT3/4, assessed by flow cytometry (Fig. 2A), and OCT4, REX1, NANOG and

• Meanwhile in vitro studies of neural induction from

  2018-11-08

  

  Meanwhile, in vitro studies of neural induction from hPSCs have suggested that radial arrangements of columnar neuroepithelial cells, termed neural rosettes, can differentiate toward peripheral nervous system (PNS) lineages (Chambers et al., 2009; Kim et al., 2010) and reported evidence of neural cr

• Chemotherapy is a standard treatment for patients

  2018-11-08

  

  Chemotherapy is a standard treatment for patients with advanced disease, including nonresectable, recurrent, or metastatic tumors. Due to chemoresistance, the majority of patients die within three years (Papaspyrou et al., 2011). Indeed, cisplatin and other platinum-based therapies do not present cl

• Here we report for the first time that the

  2018-11-08

  

  Here, we report for the first time that the mouse eye possesses a primitive c-Kit+ cell that is self-renewing, clonogenic and multipotent, the three critical identifiers of tissue specific stem/progenitor proton pump inhibitor (Weissman, 2000). In addition, lineage tracing techniques in vivo demons

• We next aimed to characterize changes

  2018-11-08

  

  We next aimed to characterize changes in huSCs during ex vivo culture, which, in mice, results in a marked reduction in the capacity for tissue regeneration and self-renewal upon subsequent transplantation (Gilbert et al., 2010; Montarras et al., 2005). For this analysis, we used a basal culture med

• We sought to determine whether T cell

  2018-11-08

  

  We sought to determine whether T cell-derived iPSCs (TiPSCs) could be used to analyze neurological diseases. Several issues regarding the utilization of TiPSCs in neurological studies remain unresolved. First, previous studies indicated that each iPSC clone retains an epigenetic memory relating to t

• This study focuses on ultimate reasons

  2018-11-07

  

  This study focuses on ultimate reasons for certain kinds of consumer behaviour. Specifically, it examines how external stimuli with adaptive objectives (e.g., mate selection, investment in family care and security) can play a more decisive role than our cognitive capabilities in modifying our decisi

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