• To prevent the negative impact of hemolysis the

  2018-11-05

  

  To prevent the negative impact of hemolysis, the U.S. Food and Drug Administration set the upper threshold of hemolysis in a RBC unit to be transfused at 1% but some RBC units stored under standard blood banking conditions fail to meet this requirement due to factors that may be donor specific (Mish

• Furthermore such classification criteria that select

  2018-11-05

  

  Furthermore, such classification criteria that select a highly specific sub-population of SS participants (those with 2 out of 3 objective signs - focus score≥1, positive serology, and ocular staining score≥3) (Shiboski et al., 2012) could challenge external validity. Therefore, clinical trial resul

• br Conclusion br Disclosure The authors declare

  2018-11-05

  

  Conclusion Disclosure The authors declare no conflicts of interest. I.R. is supported by the Wellcome Trust [103952/Z/14/Z]. Hepatocellular carcinoma (HCC) is a type of liver cancer, causing the highest mortality in the world (). Although surgical operation or other intervention therapies a

• br Concluding Remarks br Financial Disclosures br Author Con

  2018-11-05

  

  Concluding Remarks Financial Disclosures Author Contributions Role of the Funding Source Partial funding for this study was provided by a service directed grant from the U.S. Department of Veterans Affairs and the University of Minnesota (Brain and Genomics Fund and the American Legion B

• Saracatinib br New Compounds Specifically Developed to Targe

  2018-11-05

  

  New Compounds Specifically Developed to Target Ageing Biomarkers for Detecting Drug Efficacy Against Ageing To accurately assess the impact of possible therapeutics on human ageing, suitable biomarkers that correlate with, and are likely causative of, increased physiological age are needed. A

• Given the competing roles described above an

  2018-11-05

  

  Given the competing roles described above, an important question is whether treatment of cancer by autophagy inhibition will lead to neurodegenerative side effects and likewise, that treatment of neurodegenerative diseases with autophagy promoting agents might promote pre-malignant tumors. There are

• Having all kernel values available as

  2018-11-05

  

  Having all kernel values available as files on hard disk, it is possible to implement different serial or parallelized realizations of setting up and solving the (large) regularized system of linear sensitivity equations (e.g. by factorization methods or conjugate-gradient solvers) in an iteration o

• br Case report A year old boy

  2018-11-05

  

  Case report A 15-year-old boy complaining of unexplained fatigue was first attended by the pediatrics office on November 2010. Such discomfort started in June, two months after being vaccinated against the 2009 pandemic influenza A/H1N1 virus with Pandemrix™. Physical and neurological examination

• OSA is a common sleep disordered breathing characterized

  2018-11-05

  

  OSA is a common sleep disordered breathing, characterized by recurrent apneas (complete breathing cessation) or hypopneas (shallow breathing), upper airway constriction, hypoxemia, hypercapnia, autonomic activation, and EEG arousal and sleep fragmentation, leading to daytime fatigue and sleepiness [

• br Discussion Despite the recent publication of the National

  2018-11-05

  

  Discussion Despite the recent publication of the National Sleep Foundation’s Sleep duration team recommendations [1], sleep deprivation is recognized as important to public health. Industrial accidents, motor vehicle crashes and medical and other occupational errors have been associated with slee

• irak inhibitor Temperature rhythm is an important phase mark

  2018-11-05

  

  Temperature rhythm is an important phase marker for chronobiological studies, however, the use of core body temperature rhythm in longitudinal researches has always been limited by restrictions for continuous use of data recording devices, such as rectal probes. Wrist temperature, recorded by a ther

• br Fabrication and characterization of

  2018-11-05

  

  Fabrication and characterization of the device Results and discussion A picture of the fabricated system is reported in Fig. 5. The PDMS microfluidic network (the rectangular gray shape) lays in the upper right corner of the glass, the differential diode deposited on the glass substrate is hig

• In inverse problem solutions different optimization techniqu

  2018-11-05

  

  In inverse problem solutions, different optimization techniques are used to estimate time dependent parameters, often related to root searching iterative methods belonging to the family of steepest descent and scaled steepest descent methods. Textbook [34] present general methods of solution of inve

• br Acknowledgment br Experimental design materials and

  2018-11-03

  

  Acknowledgment Experimental design, materials and methods In the current work, four chalcogenide glasses with nominal atomic compositions described by SeGeIn were synthesized in from elemental Se, Ge and In (all elements were of 99.99% purity) by sealing the required quantities in quartz ampou

• pdk1 br Bioinformatics analysis of the identified proteins T

  2018-11-03

  

  Bioinformatics analysis of the identified proteins To get a precise prediction, multiple bioinformatics methods were performed. First, the mouse pdk1 thus identified were associated with their putative human orthologs using NCBI׳s HomoloGene resource. Homogene annotations were downloaded from “ft

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