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br is a bacterial infection causing necrotising lesions of
2019-05-10
is a bacterial infection causing necrotising lesions of skin and subcutaneous tissue. Widely known as Buruli ulcer, it is classified as a neglected tropical disease by WHO. If diagnosed and treated early, outcomes are good, but if left untreated it can progress to a severe disease resulting in hig
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GP ablation has been regarded as a vagal
2019-05-10
GP ablation has been regarded as a vagal denervation procedure that reduces the vagal tone in the atria and the vulnerability to AF. However, it is unclear how much vagal effect on the atrium is attenuated and how much of the atrium is denervated after the ablation. According to the GP mapping by Mc
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Heart failure is a complex
2019-05-09
Heart failure is a complex disease and the status of each patient is highly heterogeneous; therefore, nominal manufacturer-delivered device settings may not be optimal for all patients who receive CRT implantation. A growing body of evidence suggests hemodynamic and clinical status benefits associat
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We conducted a retrospective analysis to compare a BMD alone
2019-05-09
We conducted a retrospective analysis to compare a BMD-alone strategy, versus BMD+FRAX® and BMD+FRAX®+TBS screening strategies. To our knowledge, this constitutes the first study to assess the relative contributions of FRAX® and TBS. In our cohort, FRAX®+BMD identified 9 (9%) additional patients at
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THZ1 Hydrochloride En este mismo sentido Maryluz Vallejo M
2019-05-09
En este mismo sentido, Maryluz Vallejo M. afirma que: Es decir, el medio de comunicación sí ostentaba una postura política, la diferencia con los otros estaba en que dicha postura lograba congregar THZ1 Hydrochloride los partidarios de posiciones políticas contrarias y, en lugar de ser objeto de ex
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br Results Karyotyping revealed chromosomal abnormalities in
2019-05-09
Results Karyotyping revealed chromosomal abnormalities in 19 of 20 metaphase spreads examined. All abnormal metaphases had a del(14)(q22), and 17 metaphases were interpreted to contain a three way translocation, t(2;5;7)(q31;q21;q11.2) and loss of all or part of chromosome 6. FISH analysis showed
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Two months from the initiation
2019-05-09
Two months from the initiation of dasatinib, abnormal FDG uptake of the left femur tumor had disappeared. Examination of peripheral blood and the bone marrow examination showed that a complete cytogenetic response was achieved and a ratio of BCR-ABL to ABL on the international scale was 0.21%. Her d
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br Rheumatic heart disease RHD
2019-05-09
Rheumatic heart disease (RHD) affects over 32 million people worldwide; the vast majority of patients are in low-income and middle-income countries. It is a leading cause of premature mortality in children and young adults living in endemic regions. Patients with RHD often present in an advanced s
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br Efforts to address malnutrition maternal and child mortal
2019-05-09
Efforts to address malnutrition, maternal and child mortality, and other global health priorities are heavily reliant on behaviour change, including adoption and correct use of health technology, and following treatment recommendations. One long-standing concern is the limited effectiveness of man
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br Risk of bleeding complications with dual antiplatelet age
2019-05-09
Risk of bleeding complications with dual antiplatelet agents Dual antiplatelet therapy (DAPT) with combined aspirin and clopidogrel has become a standard treatment after percutaneous coronary intervention (PCI). Recent studies have examined the impact of such therapy on the incidence of bleeding
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br Authors disclosure Mark Clemons received
2019-05-09
Authors\' disclosure Mark Clemons received honoraria for talks from Novartis and Amgen, research funding from Novartis. Case In September 2007 a 9½-year-old boy was diagnosed with a Ewing sarcoma (EWS-FL1 translocation positive) of the right scapula. MRI showed a tumor of 8.0×2.9 ×6.2cm locat
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Pharmacokinetics analysis of AT on SCID mice
2019-05-09
Pharmacokinetics analysis of AT-406 on SCID mice bearing MDA-MB-231 tumors has shown that AT-406 achieves a maximum concentration in plasma between 1.5μM and 9.9μM, and a maximum concentration in tumor tissue between 0.5μM and 18.2μM, depending on the dose and administration route (intravenous versu
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In the univariate subgroup analysis
2019-05-09
In the univariate subgroup analysis, the factors that predicted reduced survival were increased age, significant mitral regurgitation (≥ grade 2), and creatinine level (Table 4). After multivariate analysis, (+)PES followed by ICD SAR302503 was a strong predictor of reduced mortality, along with cr
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purchase topirimate Atrial fibrillation is the most common a
2019-05-09
Atrial fibrillation is the most common atrial arrhythmia studied in BrS [3–14]. The prevalence of AF has been reported to be higher in patients with BrS than in the general purchase topirimate of the same age [15,16]. Earlier studies reported an approximately 10–50% prevalence of spontaneous, clinic
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br Acknowledgments We thank all the ultramarathon runners wh
2019-05-08
Acknowledgments We thank all the ultramarathon runners who participated in this study and all the doctors, nurses, and emergency medical technicians who provided professional care at the ultramarathon race. We also thank our colleagues at Soochow University, Taipei, Taiwan and the Chinese Taipei
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