• Recently as reported by Xu G et al

  2018-10-25

  

  Recently, as reported by Xu G et al., sorafenib in combination with low-dose homoharringtonine as a salvage therapy was successfully administrated and obtained CR in primary refractory FLT3-ITD mutant AML. In conclusion, regimen including HHT has been used as an alternative valid front line chemothe

• br Conclusions and future perspectives It has been suggested

  2018-10-24

  

  Conclusions and future perspectives It has been suggested that developmental mechanisms are prisoners of their own phylogenetic histories (Goss, 1991). On the basis of recent studies of cardiac regeneration in fetal/neonatal mammals, it would appear that regenerative mechanisms are also prisoners

• The following are the supplementary data

  2018-10-24

  

  The following are the supplementary data related to this article. Acknowledgments The authors wish to thank Dr. K. Inoue for the S100β/GFP-TG rats, Dr. A.F. Parlow and the NIDDK for the MLN4924 against pituitary hormones, Dr. S. Tanaka at Shizuoka University for the antibody against human ACTH

• Mari n and colleagues previously

  2018-10-24

  

  Marión and colleagues previously reported that knockout of TP53 in human and mouse fibroblasts allows for efficient reprogramming at the expense of increased DNA damage, which was attributed to a decrease in apoptosis of DNA damaged sphingosine 1-phosphate receptor modulator (Marión et al., 2009).

• orphan receptor As with reprogramming factors Oct Klf

  2018-10-24

  

  As with reprogramming factors (Oct4, Klf2, Sox2, and c-Myc), overexpression of E-cadherin enhances the efficiency of iPSC generation from mouse embryonic fibroblasts (Chen et al., 2010). We demonstrated that E-cadherin overexpression affects both attenuation of β-catenin signaling and enhancement of

• The Xenopus homolog of Bucky ball is

  2018-10-24

  

  The Xenopus homolog of Bucky ball is known as XVelo (Vegetally localized −1), first identified based on the vegetal pole localization of XVelo RNA (Claussen and Pieler, 2004). A recent study identified XVelo as a Balbiani body enriched protein, and identified prion-like sequences within the amino te

• Here we set out to investigate the progressive

  2018-10-24

  

  Here, we set out to investigate the progressive steps of hiPSC reprogramming by Phi29 DNA polymerase-based mRNA-sequencing (Phi29-mRNA amplification [PMA] RNA-seq) that enables us to monitor transcriptomes in scarce intermediate cell populations (Pan et al., 2013). We identified unique pluripotency-

• Another developmental regulator Hedgehog Hh

  2018-10-24

  

  Another developmental regulator, Hedgehog (Hh), acts as a morphogen in many developing tissues. Visceral endoderm is instructive to the development of endothelial and hematopoietic niclosamide through Hh signaling early in mouse gastrulation (Belaoussoff et al., 1998; Dyer et al., 2001). Hh protein

• Several strategies have been recently developed for

  2018-10-24

  

  Several strategies have been recently developed for CBC cell isolation via cell surface markers and fluorescence-activated cell sorting (FACS; Gracz et al., 2013; King et al., 2012; Merlos-Suarez et al., 2011; Wang et al., 2013). Although they represent considerable advances in the isolation of CBC

• blasticidin br Introduction Human pluripotent stem cells hPS

  2018-10-24

  

  Introduction Human pluripotent stem blasticidin (hPSCs) have the ability to proliferate indefinitely and the potential to differentiate into any somatic cell type in the human body (Takahashi et al., 2007; Thomson et al., 1998). They can be a great resource for the development of cell transfer-b

• br Experimental Procedures br Author Contributions br

  2018-10-24

  

  Experimental Procedures Author Contributions Acknowledgments We thank Professor Tao Cheng at the State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, CAMS & PUMC for generously providing the H1 line; Professor H. Suemori at the Laboratory of

• br Experimental Procedures br Author Contributions br

  2018-10-24

  

  Experimental Procedures Author Contributions Acknowledgments This work is supported by national Portuguese funding through FCT, Fundação para a Ciência e a Tecnologia, project UID/BIM/04773/2013 CBMR, projects PEst-OE/EQB/LA0023/2013 and PTDC/SAU-ENB/111702/2009 to J.B., U01HL100408, NIH/NH

• While we cannot exclude the

  2018-10-24

  

  While we cannot exclude the possibility that some MYB-dependent hematopoietic progenitor buy ANA 12 (HPCs)/HSCs are generated during normal WT iPSC differentiation, we would expect a reduction in monocyte/macrophage production if the majority of monocytes/macrophages were derived from MYB-dependent

• The most important contribution of

  2018-10-24

  

  The most important contribution of our study to ZIKV research is the finding of ZIKV-mediated impairment of hNSC neuronal differentiation in a cell-strain-dependent manner. Specifically, ZIKV infection significantly reduced neuronal differentiation of K054 and K048 strains but not G010. Both RNA seq

• It is important to note that

  2018-10-24

  

  It is important to note that although RB1 inactivation is unique to retinoblastoma initiation, it is functionally inactivated in most human neoplasms (Weinberg, 1995); therefore, utilizing RB1-mutant nmda receptor antagonist as a drug screen platform could benefit other malignancies as well. In con

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