• 2858 sale br Author contributions br Funding

  2024-02-05

  

  Author contributions Funding This work was supported by the Czech Science Foundation, project no. 14-16220S. Additional support was provided by NIH R01CA117907 grant awarded to J.M.E. Conflict of interest Introduction The dioxin-like family includes polyhalogenated aromatic hydrocarbons

• AdipoR and AdipoR have been reported to

  2024-02-05

  

  AdipoR1 and AdipoR2 have been reported to be present in almost all type of tissues and low ornidazole levels have been observed in white adipose tissue (Inukai et al., 2005). These receptors have been observed to become deregulated with the onset of obesity, resulting in a reduced level of APN expr

• In addition to the above mentioned synaptic mechanisms the

  2024-02-05

  

  In addition to the above-mentioned synaptic mechanisms, the serotonergic system also has a critical role in the antidepressant effects of mGlu2/3 receptor antagonists. Indeed, we previously reported that mGlu2/3 receptor antagonists increased the firing rate of serotonin neurons in the dorsal raphe

• cftr channel br Materials and methods br Results br

  2024-02-04

  

  Materials and methods Results Discussion Cdc42 has been implicated in mediating the entry of HCV into hepatocytes, but how Cdc42 affects the response of HCV patients to IFN therapy is unknown. This study therefore examined the genetic association between Cdc42-related genes and efficacy of

• Application of the broad acting HTR

  2024-02-04

  

  Application of the broad-acting 5-HTR antagonist methiothepin (Bard et al., 1996, Hoyer et al., 1994, Peroutka, 1990) converted the TBS-induced response of both thalamocortical and intracortical A1 synapses from LTP to LTD, an effect that was mimicked by the selective 5-HT2R antagonist ketanserin (L

• It is increasingly evident that many metabolic genes are

  2024-02-04

  

  It is increasingly evident that many metabolic genes are associated with cancer progression of various tumor cells, including NSCLC. In particular, GLUT1 overexpression has been reported in NSCLC, and correlations between GLUT1 expression and a number of clinical parameters such as gender, smoking s

• br Antifungal resistance what is in a

  2024-02-04

  

  Antifungal resistance, what is in a name? Antifungal resistance is an emerging and hot topic in the field of medical mycology. Microbiological resistance is identified by determining minimal inhibitory concentrations (MICs) in vitro for a given antifungal and interpreting this value according to

• br Materials and methods br Results br

  2024-02-04

  

  Materials and methods Results Discussion Our results revealed that LPS injection in rats impaired fear memory in the PA task. This results are in agreement with the most of previous studies reported that following acute [23,24,39,[45], [46], [47]] or chronic systemic punicalagin [30] fear

• br Conclusion We have identified three non

  2024-02-04

  

  Conclusion We have identified three non-competitive inhibitors of the human and porcine APN with Ki values in the μM range, by combining virtual screening and kinetic assays. Molecular docking simulations suggest these novel inhibitors block APN activity by an alternative mechanism to Zn coordina

• Inflammatory factors released by activated

  2024-02-04

  

  Inflammatory factors released by activated cells during AD are very important for the disease progression. Not only several inflammatory cytokines, such as IL-1β, IL-18, and IL-33, but also anti-inflammatory ones, as IL-10 and IL-13, are upregulated in the brain of AD patients (Morimoto et al., 2011

• To examine whether the interaction between

  2024-02-02

  

  To examine whether the interaction between mGlu7 and α1-adrenergic receptors could be confirmed at a behavioural level, we performed the FST in mice. This test has value in predicting the antidepressant-like effect of drugs or environmental manipulations (Krishnan and Nestler, 2008, Krishnan and Nes

• In conclusion this study detected the

  2024-02-02

  

  In conclusion, this study detected the expression of adiponectin and its receptors, AdipoR1 and AdipoR2, in goat ovarian follicles. In addition, adiponectin was shown to enhance the progression of goat oocyte nuclear maturation in vitro. The present findings provide evidence for paracrine/autocrine

• br Effective therapeutic window of AR actions on ROP

  2024-02-02

  

  Effective therapeutic window of AR actions on ROP Retinal vasculature undergoes critical developmental changes postnatally: from P7 onward the superficial Triclosan australia start sprouting vertically in retina to form first the deep then the intermediated vascular plexus in the retina of C57BL/

• br Material and methods br Results br Discussion T

  2024-02-02

  

  Material and methods Results Discussion T2D is a substantial threat to global human health [31]. Obesity-associated chronic low-grade inflammation promotes insulin resistance and T2D [32]. In obese individuals, the production of numerous inflammatory molecules including IL-6 and TNF-a is up

• About this report Alzheimer s

  2024-02-01

  

  About this report 2018 Alzheimer's Disease Facts and Figures is a statistical resource for U.S. data related to Alzheimer's disease, the most common cause of dementia. Background and context for interpreting the data are contained in the Overview. Additional sections address prevalence, mortality a

16104 records 181/1074 page Previous Next First page 上5页 181182183184185 下5页 Last page