• br Competing interests br Acknowledgments This research

  2023-08-23

  

  Competing interests Acknowledgments This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (NRF-2014R1A4A1071040). Introduction Mitochondria occupy an important position as mediators of

• At the organismal level skeletal muscle lung and adipose

  2023-08-23

  

  At the organismal level, skeletal muscle, lung and adipose tissues mediate net de novo synthesis and release of glutamine, whereas net glutamine catabolism occurs in the kidney [7]. The liver exhibits net glutamine consumption coupled to urea production in the post-absorptive state, and net glutamin

• There are some limitations and further experiments that are

  2023-08-22

  

  There are some limitations and further experiments that are required. First, to our surprise, measurement of the cardiomyocyte cross-sectional area in Akt1−/−/iAkt2 KO mice showed comparable areas to WT mouse despite of reduced heart weight. In addition to measuring cardiomyocyte cross-sectional are

• Our results showed that oral administration of cordycepin in

  2023-08-22

  

  Our results showed that oral administration of cordycepin, in the concentrations of 5 and 10mg/kg for 3weeks, exerted no influence on body weight and hippocampus weight in mice. Although some reports have pointed out that cordycepin had toxic effects because it may be potential for inducing cell dea

• For comprehensive understanding of actin myosin XI as a

  2023-08-22

  

  For comprehensive understanding of actin-myosin XI as a control network, it will be necessary to determine the functions of all the myosin XI and igf1r inhibitor isoforms. However, it is difficult to reveal the function of individual myosin XI isoforms because most myosin XI single knockouts exhibi

• The adult muscle type acetylcholine receptor

  2023-08-22

  

  The adult muscle-type JNJ-26854165 receptor (AChR), the exemplar pLGIC, is a heteropentamer comprising two α subunits, and one each of the β, δ, and ɛ subunits (Sine, 2012). These five subunits come together in a counterclockwise α-ɛ-α-δ-β arrangement (Figure 1A). Binding of acetylcholine to the AC

• Autotaxin has been linked to chemoresistance through

  2023-08-22

  

  Autotaxin has been linked to chemoresistance through its ability to inhibit apoptosis induced by paclitaxel in breast cancer Mepivacaine HCl [15] and LPA can inhibit cell death induced by cisplatin [40]. Autotaxin was included in the present study because it was identified as being over-expressed i

• br Ataxia telangiectasia and Rad related

  2023-08-22

  

  Ataxia–telangiectasia and Rad3 related as a therapeutic target Several concerns revolving around functional inhibition of ATR have hindered the exploitation of ATR as therapeutic target in cancer therapy and delayed the development of specific ATR kinase inhibitors. It was anticipated that pharma

• br Conclusion br References and recommended

  2023-08-22

  

  Conclusion References and recommended reading Papers of particular interest, published within the period of review, have been highlighted as: Acknowledgements Introduction Nucleosome, the basic chromatin unit, is composed of DNA and core histones (H2A, H2B, H3 and H4) and organized into

• In fact serotonin is a

  2023-08-21

  

  In fact, serotonin is a major modulator of dopaminergic (DA) neuronal activity through the 5-HT2C receptor. Studies have shown that the selective 5-HT2C receptor agonist Ro60-0175 blocks the burst-firing of mesolimbic DA neurons, which project from the ventral tegmental area (VTA) to the nucleus acc

• NLX a k a F or befiradol exhibits nanomolar

  2023-08-21

  

  NLX-112 (a.k.a. F13640 or befiradol), exhibits nanomolar affinity at 5-HT1A receptors, and, in 5 aminosalicylic acid to the 5-HT1A receptor agonists listed above, it presents exceptional selectivity and high efficacy at these receptors (Colpaert et al., 2002, Newman-Tancredi et al., 2017). Addition

• As we previously observed in the NSFT

  2023-08-21

  

  As we previously observed in the NSFT (Fukumoto et al., 2014), the effect of LY341495 in the FST was also inhibited by a 5-HT1A receptor antagonist, indicating the role of the 5-HT1A receptor in the actions of LY341495. Among the 5-HT1A receptors, which exist both presynaptically and postsynapticall

• Adenosine is an endogenous nucleoside

  2023-08-21

  

  Adenosine is an endogenous nucleoside that plays pivotal roles in different physiological and pathophysiological processes by triggering specific cell-surface receptors both in the VX-702 and in the periphery. The adenosine receptors (ARs) are four different subtypes of G protein-coupled receptors

• Adenosine is an endogenous nucleoside

  2023-08-21

  

  Adenosine is an endogenous nucleoside that plays pivotal roles in different physiological and pathophysiological processes by triggering specific cell-surface receptors both in the YM 155 and in the periphery. The adenosine receptors (ARs) are four different subtypes of G protein-coupled receptors

• We have previously reported alterations of the thymus

  2023-08-21

  

  We have previously reported alterations of the thymus in AChR-MG patients, especially in their germinal center AS-605240 (defined as CD19+CD38+ cells by flow cytometric analysis). First, we found that, in MG thymi, this subset failed to show the normal down-regulation of Bcl-2, suggesting that auto

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