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br Cholecystokinin CCK CCK is secreted by enteroendocrine I
2022-05-21
Cholecystokinin (CCK) CCK is secreted by enteroendocrine I-cells of the duodenum and jejunum in response to amino acids and lipids [14]. There are two forms of the CCK receptor, CCK1 which is expressed on pancreatic α- and β-cells while CCK2 is located on somatostatin-secreting δ-cells [8]. CCK r
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GPR belongs to the G protein coupled receptor family
2022-05-21
GPR84 belongs to the G protein-coupled receptor family, and it was first identified from human peripheral blood neutrophils [,]. GPR84 is now considered to be a member of receptor for medium chain fatty SB 203580 hydrochloride (MCFA) with carbon chain lengths of 9–14 []. GPR84 is mainly expressed in
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Introduction Gestational diabetes mellitus GDM is one
2022-05-21
Introduction Gestational diabetes mellitus (GDM) is one of the most common complications associated with pregnancy [1]. Approximately 7.6% of pregnancies in the United States are complicated by GDM [2,3], which significantly increases the mother's risk of developing type 2 diabetes (T2D) later in l
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br Results and discussion br Conclusion In conclusion our pr
2022-05-21
Results and discussion Conclusion In conclusion, our present results indicated that l-glutamate treatment could induce resistant to B. cinerea in postharvest tomatoes. The control effect was probably associated with up-regulating the glutamate receptor-like genes, PR genes and the accumulation
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br Materials and methods br Results br Discussion In
2022-05-21
Materials and methods Results Discussion In the CNS, GLP-1R is associated with G-protein signal transduction pathways, which can activate adenylyl cyclase and protein kinase A by cyclic adenosine monophosphate, and mediates neuronal activities implicated in various pathophysiological change
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br A small conductance chloride channel SCC In addition
2022-05-21
A small conductance chloride channel (SCC) In addition to the above-described channels, a 5pS SCC has been encountered in electrophysiological recordings. This channel, exhibiting long periods of opening separated by long intervals of closing, showed the same characteristics as the SCC described
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Recently the classical view of the compartmentalization
2022-05-20
Recently, the classical view of the compartmentalization of the plant isoprenoid metabolism has been re-evaluated, following the demonstration of the partial peroxisomal localization of the mevalonic ONO-5046 receptor (MVA) pathway, generally regarded as cytosolic. Using GFP-tagging approaches, the
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PKC does not however directly stimulate secretion by initiat
2022-05-20
PKC does not, however, directly stimulate secretion by initiating calcium influx into the cell [51]. Work from multiple groups measuring calcium currents has shown that PMA alone or coupled with glucose does not modulate intracellular calcium influx [34], [51], [52], [53]. Instead of contributing t
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Previous studies have shown that
2022-05-20
Previous studies have shown that inhibition of voltage-gated Na+ maprotiline has a reduced effect on GABAergic boutons compared with other neurotransmitter phenotypes,46, 47 and voltage-gated Na+ channel subtypes are differentially expressed in hippocampus. In addition, SV exocytosis evoked by eleva
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Histamine in the central nervous system is
2022-05-20
Histamine in the central nervous system is produced mainly in the tuberomammillary nucleus and is implicated in learning and memory as well as sleep and wakefulness, feeding and drinking, and neuroendocrine regulation . For instance, treatment with antihistamines not only produces drowsiness but als
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In hypoxic breast cancer cells
2022-05-20
In hypoxic breast cancer cells, BNIP3-mediated autophagy activation and elevation of amino Posaconazole levels were notable. BNIP3, a BCL-2 family protein, is known to be transcriptionally regulated by HIF-1α and to be involved in cancer cell death in hypoxic conditions [51]. As a link to autophagy,
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(-)-Bicuculline methiodide br HO and cerebral malaria
2022-05-20
HO-1 and cerebral malaria In a post-mortem evaluation of human cerebral (falciparum) malaria, strong HO-1 immunostaining was consistently noted in microglia/macrophages within and surrounding the pathognomonic Durck’s granulomas (Schluesener et al., 2001). As witnessed in cerebral trauma specimen
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Our investigation also showed NAC increased the level
2022-05-20
Our investigation also showed NAC increased the level of DAF and might protect HUVECs from complement activation. NAC, an antioxidant/mucous modifier, has displayed benefits in chronic obstructive pulmonary disease. Martinez de Lizarrondo et al [38] provided evidence that the molecular target underl
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The central region of Azalanstat can be substituted
2022-05-20
The central region of Azalanstat can be substituted with connecting alkyl chains of different nature and length. Interesting results were given by compounds with a four or five tcs products chain, incorporating heteroatoms, such as oxygen (Fig. 2, compound 4) or sulfur, and different functional grou
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br Hedgehog in chronic liver disease The liver
2022-05-20
Hedgehog in chronic liver disease The liver responds to different chronic insults with a highly conserved wound healing response during which different cell types must communicate to reconstruct fully functional, healthy liver parenchyma. The inter-cellular dialogue that orchestrates effective li
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