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br Acknowledgements We thank the following individuals for
2022-03-29
Acknowledgements We thank the following individuals for notable contributions to this work: Dr. Ruth Wood, Dr. Alan Watts, Dr. Casey Donovan, Andrea Suarez, Emily Nakamoto, Allison Apfel, April Banayan, and Jonathan Cheung. This study was supported by the National Institute of Health grants, DK10
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br Voltage dependent anion channel
2022-03-29
Voltage-dependent anion channel VDAC is a ubiquitous protein showing well conserved structural and functional properties in spite of major variations in its sequence (for review see [50]). Most of what we know about VDAC electrophysiological properties (for reviews, see [51], [52]) was initially
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L002 br Concluding remarks In this small material of thirtee
2022-03-29
Concluding remarks In this small material of thirteen pituitary tumors of various kinds, we could not run statistical analysis. However, with a follow-up period of up to five years, we show that Disclosure Statement Acknowledgments Introduction Galanin is a 29/30-residue neuropeptide fo
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br Results br Discussion The inflammasome consists of the
2022-03-29
Results Discussion The inflammasome consists of the sensor molecule nucleotide oligomerization domain (NOD)-like receptors (NLRs), the adaptor protein ASC, and the MLN0128 molecule CASP1 (Guo et al., 2015). Among the different types of inflammasome, the NLRP3 inflammasome requires a priming s
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With the nitrogen containing heterocycle components and the
2022-03-29
With the nitrogen-containing heterocycle components and the acidic components in hand, the final products were synthesized according to the procedure as depicted in . Reaction of – with various β-substituted phenylpropionic Altiratinib australia (, and ), followed by deprotection by TFA, smoothly pr
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Through the analysis of various synthetic
2022-03-29
Through the analysis of various synthetic GPR40 agonists as reported in literature, we found that a number of these compounds contained a phenylpropanoic GSK1324726A motif which was inspired from naturally occurring medium to long chain fatty acids. For instance, in the early period of discovering
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br Acknowledgements br Introduction Muscle FBPase is very se
2022-03-29
Acknowledgements Introduction Muscle FBPase is very sensitive to AMP inhibition and in the presence of physiological concentrations of this effector in muscle fibres FBPase should be almost completely inactive [1], [2]. Recently, we have presented evidence that, in vitro, muscle aldolase binds
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According to the implication of the endocannabinoid
2022-03-28
According to the implication of the endocannabinoid system in IBD, we decided in our laboratory to develop selective CB agonists and FAAH inhibitors to treat these diseases. Recently, we described 3-carboxamido-5-aryl-isoxazoles as selective CB agonists. This series of isoxazoles possesses a 2-subst
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br Application of TIRFM to
2022-03-28
Application of TIRFM to visualizing exocytosis TIRFM was first used to visualize exocytosis from large secretory granules from chromaffin serotonin receptors (Steyer et al., 1997). Before that, visualization of secretory organelle was strictly limited to a few exceptions, such as mast cell of mut
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In NAFLD models the first hit is liver fat
2022-03-28
In NAFLD models, the “first hit” is liver fat accumulation, which causes insulin resistance, whereas the interplay of inflammatory cytokines, which causes inflammation, acts as the representative “second hit” [9]. However, recently, the “multiple hit” hypothesis has taken into consideration that mul
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Whether histamine receptor distribution is altered in canine
2022-03-28
Whether histamine receptor distribution is altered in canine GI diseases remains unknown, but human research has documented altered histamine receptor density in certain GI diseases (Sander et al., 2006, Deiteren et al., 2015, Von Rahden et al., 2011). Additionally, a novel H4 receptor antagonist, J
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Conflicting data concerning the involvement of
2022-03-28
Conflicting data concerning the involvement of H2R on glycaemia has also arisen. Its antagonism was reported to decrease [35], not affect [36], [37] and increase [38], [39] ccgs receptor levels. In comparison, the clinical experience with antipsychotic drugs generated clearer evidence for the invol
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br Acknowledgments This study was financially
2022-03-28
Acknowledgments This study was financially supported by National Science Center Poland grant No DEC-2011/02/A/NZ4/00031 (KKK), Jagiellonian University Medical College (Poland) grants: K/ZDS/007130 (SM) and K/ZDS/007131 (SM), COST Action CA15135 (DŁ, HS, KKK) and DFG INST 208/664-1 FUGG (HS). Than
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br Concluding Remarks One of the
2022-03-28
Concluding Remarks One of the remarkable features of Hippo signaling is its sensitivity to the cytoskeleton and mechanical forces. Progress has been made recently in identifying molecular mechanisms by which the cytoskeleton can influence Hippo signaling, but among the many outstanding questions
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br Acknowledgments The work in the Vancurova lab is supporte
2022-03-28
Acknowledgments The work in the Vancurova lab is supported by St John’s University, and by NIHCA202775 grant. HDACs are Epigenetic Achilles’ Heels in Tumors with ICLs On the one hand, proficient and accurate DNA repair mechanisms ensure the genomic integrity of cells. On the other hand, the D
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