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Similar to GPR A activation of
2021-12-20
Similar to GPR109A, activation of G-protein-coupled receptor 81 (GPR81, also called HCAR1 (hydroxycarboxylic 8-Bromo-cGMP, sodium salt australia receptor 1)) by lactate suppresses lipolysis (Fig. 1), suggesting GPR81 to be a potential drug target for treating T2DM (Boyd et al., 1974, Cai et al., 200
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br GluR A knockout mice Genetically modified adult
2021-12-20
GluR-A knockout mice Genetically modified, adult mice lacking the GluR-A AMPA receptor subunit exhibit fast synaptic transmission in the hippocampus, mediated by the receptors formed from the remaining AMPA receptor subunits GluR-B and GluR-C (Sommer et al., 1991), but are deficient in a rapidly
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Animal studies have shown that various antidepressant
2021-12-20
Animal studies have shown that various antidepressant treatment are capable of upregulating GR protein and mRNA in key more hints regions including the hippocampus and decreasing basal and/or stress-induced glucocorticoid secretion [37]. Changes in the level or function of GR regulate the negative
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How do myofibroblast sources compare between bone
2021-12-20
How do myofibroblast sources compare between bone marrow and other organs? Perivascular nicotinic receptor with MSC properties significantly contribute to fibrosis in muscle, fat, skin, heart, kidney, lung, and liver (reviewed in Iwayama et al., 2015) and activate Gli1 in many of these organs (Kram
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Z-VEID-FMK In a series of experiments the clotrimazole conce
2021-12-20
In a series of experiments, the clotrimazole concentration was varied and the NSVDC channel conductances were calculated from Eq. (1) to obtain the dose-response relation (Fig. 3). The data were fitted to the Michaelis–Menten-type activation curve (Eq. (3)) and gave an EC50 value of 14 μM and a dose
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There have already been many reports on the
2021-12-20
There have already been many reports on the AFS gene (Beuning et al., 2010, Green et al., 2007, Li et al., 2006, Pechous and Whitaker, 2004, Pechous et al., 2005, Yuan et al., 2007, Yuan et al., 2010) and HMGR gene (Pechous and Whitaker, 2002, Rupasinghe et al., 2001). The recent advances concerning
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The current lack of effective treatments
2021-12-20
The current lack of effective treatments for primary or metastatic UM leaves a large therapeutic gap for patients and clinicians underscoring an urgent need for the identification of additional pharmacological targets for therapeutic intervention. As YAP-targeting strategies have remained elusive th
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The current study aimed to understand the roles and the
2021-12-20
The current study aimed to understand the roles and the underlying mechanisms of XIST in LSCC, by focusing on the regulation by miR-124-3p, which was previously identified as a target of XIST [12]. We found that the XIST expression is positively correlated with the stages of LSCC in patients. Knockd
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br Materials and methods br Results and discussion
2021-12-20
Materials and methods Results and discussion To analyze the dependence of lysosomal exocytosis on Cu we exposed HeLa a66 australia to fresh buffer containing normal levels of free Ca (1mM) and measured β-hex levels in the extracellular medium, followed by measuring β-hex content in the total
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It is well known that
2021-12-20
It is well known that histamine functions not only as an inflammation mediator but also as an aminergic neurotransmitter or neuromodulator. Histaminergic neurons [27], [28] and histamine receptor subtypes (H1R [29] and H3R [30]) are widely existed in mammalian central olfactory system. Histamine re
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Fmoc-Gly-OH br Conflict of interest br Acknowledgements This
2021-12-20
Conflict of interest Acknowledgements This work was funded by the University of Turin (ex60% 2014), World Wide Style Project (WWS; University of Turin/Fondazione CRT) and University of Florence (ex60% 2014). ACR and AP designed the study; AP, EB and IO conducted the literature search and analy
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It is important to mention that the IC of
2021-12-20
It is important to mention that the IC50 of cetirizine needed to achieve histamine H2 receptor desensitization was 0.43 µM or 170 ng/ml (Fig. 1B), becoming clinically relevant since pharmacokinetic studies after oral administration of the clinically used dose (10 mg/day) reported a maximal plasma co
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Several studies have also shown that HK may be an
2021-12-20
Several studies have also shown that HK2 may be an important downstream 22 9 mg of the PI3K/AKT/mTOR signaling pathway and may contribute to the development of cancer [15]. In our previous study, we found AKT2 expression was positively correlated with HK2 expression in primary colon cancer specimens
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It has been reported that expression of murine haspin is
2021-12-18
It has been reported that expression of murine haspin is found only in post-meiotic spermatids and that overexpression of murine haspin in HEK-293 cells leads to reduced cell proliferation. Therefore, it was suggested that haspin functions to bring about Sennoside D arrest in haploid germ cells (Ta
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br Conclusion br Conflict of
2021-12-18
Conclusion Conflict of interest statement Acknowledgements This work was supported by the National Science Foundation (MCB-1817417 to S.D.) and National Institutes of Health (R01-GM72711 to A.C.D.). We thank members of the Delaney laboratory for careful reading of the manuscript and helpful
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