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Hepatic steatosis is strongly associated
2021-08-09
Hepatic steatosis is strongly associated with insulin resistance. Numerous studies in humans and animals have shown that insulin-resistant states are often accompanied by hepatic steatosis (Angulo and Lindor, 2001, Marchesini et al., 1999, Marchesini et al., 2005, Petersen and Shulman, 2006, Seppala
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br Introduction Benzanthrone BNZ is a
2021-08-09
Introduction Benzanthrone (BNZ) is a dye intermediate used in the synthesis of number of polycyclic vat and disperse dyes. It has been detected as an environmental pollutant in urban ambient air particulates, originating from furnace effluents, municipal refuge, wood and coal combustion and autom
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Based on the finding described
2021-08-09
Based on the finding described above, the present study was designed to investigate the effects of specific CRF receptors, CRF1 and CRF2, in the BLA and CeA on the duration of TI in guinea pigs (Cavia porcellus). To this end, we evaluated whether administration of the CRF1 Alisertib synthesis antag
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GPCR Compound Library In contrast to PEGylated proteins whic
2021-08-09
In contrast to PEGylated proteins which tend to have reduced GPCR Compound Library in the body relative to their native counterparts, proteins conjugated to albumin tend to accumulate in certain locales in vivo. This means that albumin-based drug carrier systems have particular applications in the
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Neuroinflammation is the one of
2021-08-09
Neuroinflammation is the one of the emerging causal factors contributing to these cognitive deficits. Therefore, we further tested the hypothesis that neuroinflammation is a key component contributing to the progression of spatial memory deficits during HH. Spatial memory deficits were observed afte
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The aim of this study was to
2021-08-09
The aim of this study was to use molecular methods to characterise C. difficile isolates circulating in the Czech Republic from 2013 to 2015. Material and methods Discussion During a three-year period (2013–2015) a total of 32 hospitals voluntarily participated in this project, but only 11 ho
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Notably HSP expression is under control of the tetrameric fo
2021-08-09
Notably, HSP27 expression is under control of the tetrameric form of CK2 holoenzyme, as knockout or knockdown of the β regulatory subunit alone reproduces the same effects of targeting the α/α′ catalytic subunits. This observation discloses the possibility to use more specific drugs that affects onl
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br Acknowledgements br Introduction Water and
2021-08-09
Acknowledgements Introduction Water and electrolytes constitute an integral part of all living things, and PSI-6206 australia governing their movements play important roles in a wide variety of physiological and/or pathophysiological processes. Given the importance of channel proteins in canc
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br Materials and methods br Results br
2021-08-06
Materials and methods Results Discussion This study demonstrates that various progestogens combined with E2 had different effects on breast cell growth. These effects had an inverse correlation with the changes of the PRA/PRB ratio. E2's antiapoptotic effects on MCF-7 trans-4-Hydroxycrotoni
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br Materials and methods br Results
2021-08-06
Materials and methods Results Discussion DUSP1 is a member of the subfamily of the Dusl specific phosphatases (DUSPs). High levels of DUSP1 observed in lung, liver and placenta, and low levels have been found in the maprotiline australia and kidney. DUSP1 has been shown to be elevated in va
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The redox sensitive transcription factor NF B is
2021-08-06
The redox sensitive transcription factor NF-κB is reported to play a crucial role in the COPD pathogenesis via up regulating the expression of several cytokines, chemokines, growth factors, and adhesion molecules [71]. Incidentally, we and others have shown that PARP-1 modulates the NF-κB activation
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INF39 receptor GPR also known as EBI
2021-08-06
GPR183 (also known as EBI2) is a Gαi-coupled seven-transmembrane chemotactic receptor. It is highly expressed on follicular B cells, CD4+ dendritic cells (DCs), and CD4+ T cells but is downregulated on germinal center (GC) INF39 receptor in secondary lymphoid organs and controls cell migration to ac
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br Conflict of interests br Introduction Ubiquitylation
2021-08-06
Conflict of interests Introduction Ubiquitylation is a post-translational modification which impacts almost every biological process in the cell. Dysregulation of the ubiquitylation pathway is associated with several diseases, including cancer, neurodegenerative disorders, and immunological dy
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br Transparency document br Main Text
2021-08-06
Transparency document Main Text The centrosome is a non-membrane-bound organelle found in most animal cells. It has several important functions, including control of cilia formation, microtubule organization and nucleation, spindle assembly and transport of organelles and vesicles. Centrosomes
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Concerning family A GPCRs although it
2021-08-06
Concerning family A GPCRs, although it has been described that several receptors are able to operate as monomers (Arcemisbéhère et al., 2010; Bayburt et al., 2011; Chabre & le Maire, 2005; Ernst, Gramse, Kolbe, Hofmann, & Heck, 2007; Hanson et al., 2007; Kuszak et al., 2009; Whorton et al., 2007), e
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