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Udenafil also has shown the ability to
2021-07-22
Udenafil also has shown the ability to significantly inhibit the decrease of vascular endothelial cell function and inhibit the decrease in endothelial cell and smooth muscle contents, thus preventing their fibrosis within the penile corpus cavernosum in diabetic or hyperlipidemic animal models when
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Conessine br Conclusion To our knowledge this
2021-07-22
Conclusion To our knowledge, this study is the first to give evidence that the ETA selective antagonist BQ-123 reverses the cisplatin-induced ARF mainly via restoring SOD activity, in addition to other antioxidant parameters, NO, TNF-α and caspase-3 levels. And that this protective effect require
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Epiandrosterone br Results and discussion Analysis of experi
2021-07-22
Results and discussion Analysis of experimental data indicates that the radon Epiandrosterone coefficient in OPC blended with RHA varies from 0.15 × 10−6 m2 s−1 for pure cement to 0.26 × 10−6 m2 s−1 for cement mixed with 50% RHA by weight. The value of diffusion coefficient first decreases in ce
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Recent studies have shown that the extracellular regulated p
2021-07-22
Recent studies have shown that the extracellular regulated protein kinase 1 and 2 (ERK1 and ERK2), commonly referred to collectively as ERK 1/2, are members of the mitogen-activated protein kinase (MAPK) family. This family of kinases transport signals from the surface of the cell to the nucleus, th
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Like all other cellular processes ubiquitination
2021-07-22
Like all other cellular processes, ubiquitination is also tightly regulated; more so, as myriads of pathways are controlled via this conjugation and dysregulation of ubiquitination has been implicated in various diseases including cancer [16], [17]. Quite a few of such regulatory mechanisms that con
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For the SAR optimization of the
2021-07-21
For the SAR optimization of the right hand side, it was decided to explore the inclusion of the key carboxylic IT-901 moiety present in the original DGAT-1 inhibitors from . Analogs were constructed by the synthetic routes outlined in , . In , the methylene-oxy linker was introduced by condensation
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T7 High Yield Cy5 RNA In order to assess quantitatively the
2021-07-21
In order to assess quantitatively the contribution of the ung, dug and dut T7 High Yield Cy5 RNA to uracil-DNA accumulation in E. coli, we have developed a novel method for measuring uracil residues in DNA that is based on the approach of Kow and co-workers [33] for measuring AP-sites in DNA. The m
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As temperatures increase rates of spontaneous deamination al
2021-07-21
As temperatures increase, rates of spontaneous deamination also increase such that hyperthermophilic organisms must have efficient mechanisms for dealing with this potential hazard.8., 9. The hyperthermophile Methanococcus jannaschii has both a dCTP deaminase (encoded by the gene at locus MJ0430) an
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br As DAPK is dependent on
2021-07-21
As DAPK1 is dependent on Ca2+/CaM for its activity, its role in induction of autophagy is Ca2+-dependent and will be described in Section 5.1. LRRK1 and 2 were however shown to regulate autophagy in numerous studies where the role of Ca2+ was not investigated, and these mechanisms will be describe
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survivin (baculoviral IAP repeat-containing protein 5) (21-2
2021-07-21
Materials and methods Results Discussion In this study, we developed a new CysLT1 and CysLT2 receptors-mediated survivin (baculoviral IAP repeat-containing protein 5) (21-28) guinea pig model for screening both CysLT2 receptor and CysLT1/2 receptor antagonists. Unlike human CysLT2 receptors
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br Acknowledgements We thank Jeffrey D Konowalchuk
2021-07-21
Acknowledgements We thank Jeffrey D. Konowalchuk and John Sony Robbins for their technical assistance. This work was supported by Natural Sciences and Engineering Research Council of Canada (NSERC) grants to DRB (RGPIN-2013-355303) and MB (RGPIN-2014-96395). AMR was supported by NSERC Vanier Doct
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br Conclusions br Acknowledgements This work was
2021-07-21
Conclusions Acknowledgements This work was supported by funding from the Natural Sciences and Engineering Research Council of Canada (RGPIN-2017-06346 to JB), National Institute of Child Health and Human Development (5R01HD083930-02 to JB), and the National Institute of Biomedical Imaging and
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It is generally thought that the nature of a memorial
2021-07-21
It is generally thought that the nature of a memorial and the meaning attributed to it mibefradil by a tourist determines, at least in part, the behaviour that is socially appropriate (Mayo, 1988). Duncan (1995) argues however, that certain places are structured in such a way that they facilitate r
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Calcium Gluceptate br Acknowledgements Professor Olli A J nn
2021-07-21
Acknowledgements Professor Olli A. Jänne is warmly thanked for support and for providing excellent research facilities. Professor Patrik Finne is acknowledged for his help with statistical analyses. Drs Ronald Evans, Vincent Giguère, Jorma Palvimo, Malcolm Parker, and Anastasia Kralli are acknowl
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Rapamycin Introduction PGE is a major mediator present at si
2021-07-21
Introduction PGE2 is a major mediator present at sites of inflammation [1]. It is well established that PGE2 contributes to the localized and systemic symptoms of inflammation. A key study by Portanova et al. [2] demonstrated that anti-PGE2 Rapamycin were able to reverse the swelling and pain in l
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