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This article is based on previous research work
2020-09-11
This article is based on previous research work [43] in the field of distributed development of information systems [34]. In that work, the system infrastructure focusing on the three-level data model used in the different layers of our architecture is described. The work presented in this manuscrip
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It should be noted that not only glyphosate
2020-09-11
It should be noted that not only glyphosate but E2 at the same concentration range (10−11-10−7 M) also showed similar effects on the expression of the membrane transporter regulating proteins. Furthermore, we could not see a significant difference among this concentration range of glyphosate and E2
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In the present study promoting bile acid synthesis by activa
2020-09-11
In the present study, promoting bile Malonic acid synthesis by activating EP4 receptors was shown to exert protection against hepatic steatosis. This finding may be relevant for treatment of non-alcoholic fatty liver disease, a major cause of liver disease and prominent indication for liver transpl
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The following are the supplementary data related to this
2020-09-11
The following are the supplementary data related to this article. Acknowledgments Introduction Cyclooxygenases metabolize arachidonic Fmoc-Ser-OH to five primary prostanoids, PGE2, PGF2, PGI2, TXA2 (TX), and PGD2. These lipid mediators interact with specific members of a family of distinct G-
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Another important issue in biosensors
2020-09-11
Another important issue in biosensors is to design a simple and potable detection strategy to meet the requirement of the point-of-care (POC) test applications. According to the recent research, by using invertase as 481 mg for hydrolyzing sucrose into glucose, the range of personal glucometer has
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Dabrafenib High throughput screening HTS of the AstraZeneca
2020-09-10
High throughput screening (HTS) of the AstraZeneca Dabrafenib collection was conducted and identified oxadiazole amide () originating from a kinase directed screening library (although inactive against a panel of kinases). This compound had moderate potency as a DGAT-1 inhibitor (IC=0.52μM) and was
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This study was aimed to assess a number of esterase
2020-09-10
This study was aimed to assess a number of esterase activities, namely erythrocyte AChE, plasma BuChE and BeChE, and serum PON1 towards a number of substrates, as well as the major genetic polymorphisms of BCHE and PON1in a cohort of greenhouse workers exposed to low toxicity pesticides under an int
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polycomb repressive complex br Acknowledgements This study w
2020-09-10
Acknowledgements This study was financially supported by the National Special Research Programs for Non-Profit Trades (Agriculture) (Grant No. 201303045) and the Basic Foundation for Scientific Research of the State-level Public Welfare Institutes of China (Grant No. 2013JB10). Introduction L
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br Signaling of DDR receptor
2020-09-10
Signaling of DDR2 receptor and its regulation Being the tyrosine kinase receptor, downstream signaling of DDR2 receptor is initiated by phosphorylation of cytoplasmic tyrosine residue upon ligand binding (Type II collagen) but the authentic facts or detail information of tyrosine phosphorylation
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In addition to through direct regulation of cell differentia
2020-09-10
In addition to through direct regulation of cell differentiation, DDR2 may raise the abundance of myofibroblast subsets through advancing the recruitment of its precursor cells. One such evidence is that DDR2 can regulate lung fibroblast proliferation and migration. Another possibility rests on the
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Considering all these facts in the present study
2020-09-10
Considering all these facts, in the present study, we investigated the effects of two highly selective CRF receptor 2 antagonists (antisavaugine-30, ASV-30; and astressin-2B, AST-2B) on anxiety behavior in rats. The rationale for such an experimental approach was based on the premise that fear and s
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HATU synthesis Data presented herein suggest that
2020-09-10
Data presented herein suggest that competent IL-18BP production in epithelial HATU synthesis is implemented by epigenetic means based on demethylation of a single CpG site at −45 bp/−44 bp (CpG2) of the human IL18BP promoter. In contrast, retarded IL-18BP production in monocytic cells associates wi
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The proliferation of CCA cell lines can
2020-09-10
The proliferation of CCA cell lines can be stimulated by estrogen and other growth factors (Alvaro et al., 2006; DeMorrow, 2009; Mancino et al., 2009). It has also been reported that estrogen positively modulates cholangiocyte proliferation, which is associated with cholangiopathies found in humans
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We have previously shown that sustained pCPT treatment favor
2020-09-10
We have previously shown that sustained 8-pCPT treatment favored Ca2+-dependent arrhythmogenic activity in rat ventricular cardiomyocytes [8]. Fig. 2 shows line-scan Ca2+ images of myocyte incubated without (Fig. 2A left) and with 8-pCPT (Fig. 2A right) subjected to a train of electrical stimulation
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br Advent of SMEPT br
2020-09-10
Advent of SMEPT SMEPT for localized synthesis of nitric oxide Critical evaluation and outlook Examples discussed in this review present SMEPT as a methodology for localized drug synthesis – a unique opportunity for site specific therapeutic interventions using implantable biomaterials. This
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