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In vitro studies further demonstrated that S OHC may
2020-07-27
In vitro studies further demonstrated that 20(S)-OHC may also interact with membrane receptors, activating the Hedgehog signaling pathway via binding to the oncoprotein Smoothened [20]. In a similar manner 25-OHC promotes medulloblastoma growth via activation of the Sonic Hedgehog pathway [21]. Conv
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Covalent modification of activated RTKs
2020-07-27
Covalent modification of activated RTKs with ubiquitin, which is carried out by a cascade of enzymatic reactions involving E1 (ubiquitin-activating enzyme), E2 (ubiquitin-conjugating enzyme) and E3 (ubiquitin ligase), has been well established as a major mechanism for negative regulation of RTK sign
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The promoter region of the
2020-07-27
The promoter region of the detoxifying gene, GSTP1, is commonly hypermethylated in the promoter region in prostate adenocarcinoma and hepatocellular carcinoma,38, 39 but it was not hypermethylated in either oral cancer tissue, adjacent mucosa, or normal oral mucosa, as previously reported. The regul
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Flow cytometric analyses indicated that CysLT receptor posit
2020-07-27
Flow cytometric analyses indicated that CysLT2 receptor-positive leukocytes included Siglec F+ L-690,330 (eosinophils), CD11c+ F4/80+ cells (alveolar macrophages), and CD11c+ I-A/I-E+ cells (conventional dendritic cells). Only a small percentage of Gr-1+ cells (neutrophils) was positive for CysLT2
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br Materials and methods br Results br Discussion
2020-07-27
Materials and methods Results Discussion Previous studies have demonstrated that prostanoid signaling in the g15 is involved in cognitive function [8]; however, there is little evidence to indicate that the PGD2-CRTH2 signaling pathway is involved in cognitive function. The present study d
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Second when considering the Poisson point process the high
2020-07-27
Second, when considering the Poisson point process, the high-density or large-radius limit of the percolation probability tends to 1 exponentially fast and is governed by the isolation probability. In the random environment, the picture is more subtle since the regime of a large radius is no longer
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Working under the hypothesis that
2020-07-27
Working under the hypothesis that differences in COMT are associated with aberrant ethanol seeking and intake, the current project sought to investigate the influence of alterations in COMT activity and expression on alcohol seeking and drinking. While sex-linked differences in COMT protein expressi
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br Results br Discussion C is
2020-07-25
Results Discussion C4 is related to another VACV protein, C16, and the C-terminal domain of C16 also inhibits DNA-PK-mediated DNA sensing via the same mechanism and to a similar level as C4. Moreover, mutagenesis of C16 at the CYC residues equivalent to those in C4 abrogated the C16-Ku interac
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The crystal structure of LiCoO is
2020-07-25
The crystal structure of LiCoO2 is presented in Fig. 1. We can notice that the Li and Co atoms occupy the centers of two different edge-sharing [CoO6]-octahedra, which results in formation of separate Li and Co layers. Hence, the layered structure of LiMO2 is able to intercalate lithium into transit
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Among the other mediators which have been reported to play
2020-07-25
Among the other mediators which have been reported to play a role in erection are prostaglandins (PGs). Several studies have reported that alprostadil- synthetic PGE1- showed high efficacy in management of erectile dysfunction as it induces corpus cavernosal relaxation. Alprostadil has been first de
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ap1 It was reported that the expressions
2020-07-25
It was reported that the expressions of DPP-4 and SDF-1α increase through HIF-1α [27], [28]. Myocardial ischemia by MI enhanced the DPP-4 and SDF-1α levels in myocardium in the present study. SDF-1α is released from cardiomyocytes and has beneficial effects on cardiomyocytes through SDF-1α/CXCR4 aft
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Our observation that FAK is downregulated
2020-07-25
Our observation that FAK is downregulated in vascular smooth muscle AEB071 on fibrillar collagen confirms observations reported for other cell types [14]. However, unlike the results reported previously [14], our work suggests that matrix rigidity per se does not determine FAK downregulation. This
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In addition we investigated if the previously reported papai
2020-07-25
In addition, we investigated if the previously reported papain inhibitor can inhibit rhodesain, and found that it was not active at inhibiting rhodesain. The vinyl sulfone analogue of () was then synthesized and tested, and it was also inactive towards rhodesain. We then determined the time depend
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Dihydrodaidzein CXC chemokines are primarily expressed in im
2020-07-24
CXC chemokines are primarily expressed in immune organs and the central nervous system: the mouse thymus and spleen (Heesen et al., 1996), chicken bursa (Liang et al., 2001), primate (Macaca mulatta) Dihydrodaidzein (Federsppiel et al., 1993) and cattle locus coeruleus, cerebellum and pons (Rimland
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Converging evidence suggests that reduced glutamate transmis
2020-07-24
Converging evidence suggests that reduced glutamate transmission in the LS is linked to increased anxiety-like behaviors (Radulovic et al., 1999, Henry et al., 2006, Bakshi et al., 2002, Liu et al., 2004). Therefore, attenuated CRF1 receptor-mediated excitatory transmission in the LS following ASV-t
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