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In contrast to SQLE HMGCR could
2020-05-25
In contrast to SQLE, HMGCR could be efficiently degraded in SP600125 lacking UBE2J2. However, this was not the case in cells devoid of UBE2G2, as these cells were unable to support 25-hydroxycholesterol (25-HC)-stimulated degradation of HMGCR (Fig. 1C). This finding is consistent with our recently
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The intracellular redox situation of MC T
2020-05-25
The intracellular redox situation of MC3T3-E1 dextromethorphan hydrobromide after exposure with fluoride has been investigated and results revealed that the generation of ROS increased at a concentration-dependent manner, which indicated that NaF induced oxidative stress damage in MC3T3-E1 cells. F
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There is a functional ubiquitin association UBA domain at
2020-05-25
There is a functional ubiquitin association (UBA) domain at the N terminus of MCPIP1. Liang et al. have discovered that MCPIP1 may be a deubiquitinase and defined a novel DUB domain of MCPIP1 [22]. Ubiquitin and deubiquitin modification emerge as the key mechanisms that regulate the virus-induced ty
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DNA damage represents a persistent threat to genomic
2020-05-25
DNA damage represents a persistent threat to genomic stability. A critical link exists between DNA mutation, chromosomal rearrangement and cancer development. In myeloid malignancies, various chromosomal translocations and/or mutations increased cellular reactive oxygen species (ROS), followed by DS
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br Acknowledgements br Introduction Serum triglyceride
2020-05-25
Acknowledgements Introduction Serum triglyceride concentrations increase following ingestion of a fat containing meal resulting in postprandial hyperlipidemia. Peak serum triglyceride levels are observed within 2 to 4h of fat consumption and then gradually return to baseline levels within appr
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Our observation that FAK is downregulated in vascular smooth
2020-05-25
Our observation that FAK is downregulated in vascular smooth muscle Cy3 carboxylic acid (non-sulfonated) on fibrillar collagen confirms observations reported for other cell types [14]. However, unlike the results reported previously [14], our work suggests that matrix rigidity per se does not deter
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br Conclusion br Acknowledgments br
2020-05-25
Conclusion Acknowledgments Introduction Arsenic (As) is one of the most toxic metals derived from the natural environment in soil, air and well water. It has two oxidative states: a trivalent form, arsenite, and a pentavalent form, arsenate. The inorganic As is more toxic than organic As. A
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br DDR receptor and MMP expression Type II collagen
2020-05-22
DDR2 receptor and MMP-13 expression Type II collagen protein in articular cartilage is highly stable structure as its half-life is 117 years [43]. The chondrocytes have limited ability to synthesis type II collagen protein in the matrix of mature articular cartilage once the collagen gets disrupt
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isoprenaline Stress is usually comprehended as an event
2020-05-22
Stress is usually comprehended as an event affecting mainly the HPA axis and initiating the alarm reaction represented by activation of the adrenal medulla. This means that the levels of related hormones and neurotransmitters are significantly elevated during and after the stress. CRF, following its
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br Conclusion br Introduction The morphological variability
2020-05-22
Conclusion Introduction The morphological variability of aquatic plants is well documented, and in some cases has seriously constrained taxonomic resolution (Sculthorpe, 1967, Santamaría, 2002). Many of these variations are caused by the extensive phenotypic plasticity of aquatic plants, but t
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Recent studies have also uncovered additional roles for
2020-05-22
Recent studies have also uncovered additional roles for E2 enzymes and E2~Ub conjugates in modulating the activity of deubiquitinating enzymes (DUBs), such as OTUB1 (Juang et al., 2012, Wiener et al., 2013, Wiener et al., 2012). Interestingly, OTUB1 has also been shown to associate and modulate the
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The DDR gene located on chromosome region p
2020-05-22
The DDR1 gene, located on chromosome region 6p21.33, encodes a transmembrane tyrosine kinase receptor involved in melanocyte anchoring through binding to collagen IV (Silva de Castro et al., 2010). So far, only three studies have been conducted on the association between DDR1 polymorphism and the ri
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Cells expressing the CDK S D mutant exhibit
2020-05-22
Cells expressing the CDK5 S47D mutant exhibit impaired migration and enhanced proliferation: Finally, we wished to determine the functional significance of this phosphoevent. Multiple studies have implicated active CDK5 in promotion of cell migration [9,16,[21], [22], [23], [24]] and in one study th
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We propose two hypotheses to interpret our findings The firs
2020-05-22
We propose two hypotheses to interpret our findings. The first, ELR (+) CXC chemokines stimulate both CXCR-1 and CXCR-2 chemokine receptor while activating neutrophils; however CXCR-1 chemokine receptor seems to play more active role in the process of neutrophil migration as shown in previous studie
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Supported by the Austrian Science
2020-05-22
Supported by the Austrian Science Fund FWF (grant P22521-B18 to A.H.) and the Austrian National Bank (grant 14263 to A.H.). K.J. was funded by the PhD Program DK-MOLIN (FWF-W1241). Acknowledgements Introduction Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS), a more sev
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