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Tamoxifen is included in the treatment
2020-04-02
Tamoxifen is included in the treatment protocol of ER+ breast carcinoma patients routinely. Although tamoxifen improves patients\' survival, unfortunately a large number of ER+ patients don\'t response to tamoxifen treatment (Yager and Davidson, 2006). Detection of molecular markers which could take
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The following are the supplementary
2020-04-01
The following are the supplementary data related to this article. Acknowledgments Introduction Drug-resistant epilepsy (DRE) occurs in approximate 30% of patients who suffer from epilepsy [1]. Temporal lobe epilepsy (TLE) is one of the most common partial seizures and the common cause of DRE
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br Discussion EFTs are sarcomas with almost undifferentiated
2020-04-01
Discussion EFTs are sarcomas with almost undifferentiated histologic features, consequently their differentiation from other small, blue, round cell tumors may be difficult. Substantial intracellular lipoxygenase inhibitor on PAS stain is a useful diagnostic feature. The addition of CD99 and FLI
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Pyruvate dehydrogenase multienzyme complex PDHc catalyzes th
2020-04-01
Pyruvate dehydrogenase multienzyme complex (PDHc) catalyzes the oxidative decarboxylation of pyruvate, and subsequently acetylates coenzyme A (CoA) to acetyl-CoA during the tricarboxylic FTY720 Phosphate receptor metabolic pathway using thiamine diphosphate (ThDP) and Mg2+ as cofactors. PDHc poses
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The acids applied in this study are commonly
2020-04-01
The acids applied in this study are commonly used in dental practice. Phosphoric Mycophenolic acid is an oxyacid used regularly for adhesion of resin composites. Enamel phosphoric acid etching can dissolve and demineralize the inorganic [Ca10(PO4)6(OH)2] matrix, creating micro pores and microgrooves
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HvPap a member of the cathepsin F like family was
2020-04-01
HvPap-1, a member of the cathepsin F-like family, was identified in germinating barley seeds (Sreenivasulu et al., 2008). This enzyme participates in the mobilization of stored proteins (mainly hordeins) during the last phase of grain germination, and its activity is modulated by a propeptide or/and
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The results of bisaryl ether
2020-04-01
The results of bisaryl ether linker study are shown in . It was found that the methylene linker () moderately improved the binding to the DP receptor. The increased binding potency was also diminished in the presence of plasma, possibly due to higher plasma protein binding. Other linkers, such as th
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Unlike many forms of SNHL cCMV may be treatable The
2020-04-01
Unlike many forms of SNHL, cCMV may be treatable. The antiviral drug valganciclovir (VGCV) has been proposed to improve hearing, speech, and language outcomes associated with this infection [6]. A recent publication from the CASG (Collaborative Antiviral Study Group) reported that a six-month course
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The results of physical parameters of the prepared samples
2020-04-01
The results of physical parameters of the prepared samples are summarized in Table 2. The equivalent diameter ranged from 1.09 to 1.14 mm, which is within the required size distribution of 0.8–1.25 mm. A slight increase in size is probably caused by increasing the thickness of the second coat. To d
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The new ESC guidelines incorporate data from a network meta
2020-04-01
The new ESC guidelines incorporate data from a network meta-analysis of 100 studies confirming that new-generation drug-eluting stents (DES) improve survival compared with medical treatment, although this has not been demonstrated in any individual study. REVASCULARIZATION IN NON–ST-ELEVATION ACU
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br Results and discussion The effects of hypoxia a combinati
2020-04-01
Results and discussion The effects of hypoxia, a combination of shear stress and hyperoxia, and a combination of shear stress and hypoxia in BAECs were assessed at 0, 15, 30, 60, 120, and 180 min. Changes in phosphorylation levels of eNOS at Ser635 were investigated using immunoblotting, and repr
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MTX and MTXPGs block the activity of the key enzyme
2020-03-31
MTX and MTXPGs block the activity of the key enzyme DHFR (Fig. 1), which converts folates to their active forms – dihydrofolate (DHF) and tetrahydrofolate (THF). MTXPGs also potently inhibit thymidylate synthase (TS). Furthermore, during dTMP synthesis, TS utilizes the cofactor 5,10-methylene THF, w
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DAPK is a kD Ca calmodulin CaM regulated Ser
2020-03-31
DAPK is a 160-kD Ca2+/calmodulin (CaM)-regulated Ser/Thr kinase that mediates cell death. The activated forms of DAPK and DRP-1 are capable of inducing two distinct cytoplasmic events characteristic of programmed cell death, including membrane blebbing and the formation of autophagic vesicles (Inbal
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In the growth of cereal seeds there are two
2020-03-31
In the growth of cereal seeds there are two phases, development and germination, separated by dormancy. The developmental phase contains the three following stages: 1. early development including double fertilization which results in the formation of the diploid embryo (by fusion of the egg cell wit
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In summary these findings show that the knockdown of
2020-03-31
In summary, these findings show that the knockdown of tra2 in the Drosophila fat body results in an increased triglyceride phenotype, which could be explained in part by altered splicing of the gene coding for the lipid breakdown enzyme, CPT1. These findings are consistent with previous studies anal
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