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Assessment of DNA damage by
2019-11-01
Assessment of DNA damage by comet assay and ChEs activity has been widely used as a biomarker of genotoxicity and exposure to pesticide respectively, to measure the risk related to pesticides in the exposed population [15]. Very few studies have explored the association between DNA damage and worker
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On the basis of the published articles it
2019-11-01
On the basis of the published articles, it is known that chemokines are produced by leukocytes and tissue cells, constitutively or after induction. Chemokines are responsible for the recruitment of leukocytes to maintain proper functioning of the immune system [14]. They exist in the central nervous
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Fear like behaviors are produced by
2019-11-01
Fear-like behaviors are produced by intracerebroventricular CRF administration (Meloni et al., 2006, Radulovic et al., 1999), as well its administration into specific sodium channel areas such as the amygdala (Daniels et al., 2004, Donatti and Leite-Panissi, 2011), the periaqueductal gray matter (M
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br Conclusion br Experimental NMR
2019-11-01
Conclusion Experimental NMR spectra were recorded on a Jeol spectrometer at either 270 or 400 MHz for 1H spectra and either 68 or 100 MHz for 13C spectra. All chemical shifts are quoted in ppm relative to tetramethylsilane. In the assignment of signals the abbreviation DHN is used for 2,3-dihy
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MI has been detected in wastewater at concentrations of
2019-11-01
3MI has been detected in wastewater at concentrations of 640–700 μg L−1 (Hwang et al., 1995) and up to 20 mg L−1 in decaying algal water environments (Peller et al., 2014). It is likely that 3MI accumulation in fish might be due to the degradation of endogenous amino acids. The presence of this che
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br Methods and materials br
2019-10-31
Methods and materials Results Discussion Many small molecules have been individually explored to enhance endothelial barrier both in vitro and in vivo, including S1P, forskolin, cAMP analogs, ROCK inhibitors, statins, and imatinib [[10], [11], [12],25,26]. In the current study, we applied t
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br Results br Discussion In this
2019-10-31
Results Discussion In this paper we present insights into the observed specificities of inhibitors targeting the ubiquitin-activating and related E1 Darifenacin HBr mg via crystal structures of the specific NEDD8-E1 inhibitor MLN4924, the dual NEDD8/Ub E1 inhibitor ABPA3, and the selective Ub
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5-ht2 br Results and discussion br Conclusions In this work
2019-10-31
Results and discussion Conclusions In this work, we have conjugated two thermophilic enzymes (i.e., AMY and LASPO) to iron oxide NPs through different conjugation strategies obtaining efficient biocatalysts. We have demonstrated that these NP-enzyme systems can be successfully activated by an
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br Introduction Hydrogen sulfide H S and nitric oxide
2019-10-31
Introduction Hydrogen sulfide (H2S) and nitric oxide (NO) are important gasotransmitters in the cardiovascular system and instrumental to the fine control of vascular tone [1] and cellular function [2]. NO is synthesized from l-arginine by calmodulin-dependent endothelial nitric oxide synthase (e
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During germ cell development in mouse de
2019-10-31
During germ cell development in mouse, de novo Dnmts regulate the genomic imprinting and silence of repeat elements. Dnmt3A methylated H19, Dlk1/Gtl2, and Sine B1, whereas Dnmt3B methylated microsatellite repeat elements, the two Dnmts co-methylatedRasgrf1, IAP, and Line1 repeat elements (Lucifero e
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br Deregulation of CDK Many neurotoxic or stress
2019-10-31
Deregulation of CDK5 Many neurotoxic or stress conditions like ischemic CPI-455 damage, oxidative stress, mitochondrial dysfunctions, excitotoxicity, Aβ exposure lead to disruption of the tight regulation of Cdk5 (De Strooper et al., 2010). Calpain-mediated cleavage of p35 to p25 is activated un
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From materials science it is known that
2019-10-31
From materials science, it is known that the differences in the annealing temperature is the main factor that mostly influences La (Takai et al., 2003, Cançado et al., 2006). In analogy, controlling the pyrolysis temperature and S/GSK1349572 during residues burning might be a key aspect to reproduc
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Next we compared the protease
2019-10-30
Next, we compared the protease-specificity of viruses NS116-GFP/AE and NS116-GFP/AT for trypsin, neutrophilic elastase or supernatant of human neutrophils. For later purposes, we determined the viral yield in a co-cultivation system of infected Vero Blebbistatin with human neutrophils. The NS116-GF
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In contrast to inflammatory cytokines TGF has immunosuppress
2019-10-30
In contrast to inflammatory cytokines, TGF-β has immunosuppressive properties yet is also important for tissue imprinting immune cell function during development [23]. Salivary gland (SG) ILCs, in addition to liver and intestinal intraepithelial ILC1, express markers denoting tissue residency and TG
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What does this mean for
2019-10-30
What does this mean for cancer therapy? We found that components of the de novo pyrimidine synthesis pathway rarely mutate in cancer, clearly showing its importance. In our experimental models, the pathway, including DHODH itself, was primed to respond when the block in CoQ redox-cycling was removed
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