• Sulfo-Cy7 NHS Ester: Next-Generation NIR Dye for Live Bio...

  2025-09-25

  Explore the scientific foundations and unique advantages of Sulfo-Cy7 NHS Ester, a sulfonated near-infrared fluorescent dye optimized for sensitive amino group labeling and live cell imaging. This in-depth review reveals novel applications in mechanistic research and tissue transparency imaging, establishing a new benchmark for near-infrared dye use in bioimaging.

• Anti Reverse Cap Analog (ARCA): Unlocking Next-Gen mRNA T...

  2025-09-24

  Discover how Anti Reverse Cap Analog (ARCA), 3´-O-Me-m7G(5')ppp(5')G, is redefining mRNA cap analogs for enhanced translation and stability. This article uniquely explores ARCA's mechanistic impact on stem cell reprogramming and translational control in advanced mRNA therapeutics research.

• Torin2 as a Selective mTOR Kinase Inhibitor: Insights int...

  2025-09-23

  This article explores Torin2, a highly selective mTOR inhibitor, in the context of recent advances in apoptosis research. By integrating molecular details and new insights from the RNA Pol II-dependent apoptotic pathway, we provide a rigorous perspective on the use of Torin2 for dissecting mTOR signaling pathway inhibition in cancer research.

• Aberrant or a sustained activation of

  2025-03-03

  

  Aberrant or a sustained activation of AhR signaling pathway, triggered by exogenous toxic ligands such as dioxins, PAHs or polychlorinated biphenyls (PCBs), is a well-described biological process engaged during tumor initiation and/or promotion in various tissues (e.g. liver, lung, skin)(reviewed in

• Asiaticoside The decreased AR mediated response has been att

  2025-03-03

  

  The decreased βAR-mediated response has been attributed to different mechanisms, including an attenuation of PKA activation, an impaired generation of cyclic AMP, a reduced receptor density, and a less efficient coupling to adenylyl-cyclase [10]. However, currently there is no single molecular or ce

• To assess relative metabolic activity and proliferation

  2025-03-03

  

  To assess relative metabolic activity and proliferation of W146 attached to various substrates we used the MTT assay [29], [30]. In order to compare the metabolic activity of cells under the various conditions irrespective of the number or viability of the cells, we performed a PicoGreen DNA assay

• Herbal anti-inflammatory AdK as an important upstream

  2025-03-03

  

  AdK as an important upstream regulator of adenosine-based homeostasis represents a promising drug target since it leads to an increase in adenosine concentrations. Taking into account that the adenosine formation is only increased in affected tissues under stress with high adenosine levels, AdK inhi

• br Conclusion Our study of late life

  2025-03-03

  

  Conclusion Our study of late-life depression provides evidence of genotype-specific associations between depression and ACE methylation, as well as inverse correlations between ACE methylation and DASA-58 secretion. These findings highlight the potential need to consider methylation levels in co

• To date more than different mutations in the gene have

  2025-03-03

  

  To date, more than 50 different mutations in the gene have been described (Human Gene Mutation Database at the Institute of Medical Genetics in Cardiff: SRD5A2 Gene: http://www.hgmd.cf.ac.uk). Most of them are missense mutations but premature stop codons and deletions leading to non-functional or su

• In the final set of experiments the dependence

  2025-03-03

  

  In the final set of experiments, the dependence of the reaction rate on viscosity was determined. The experimental protocol previously used to study the reaction of LOX with AA was used., Reactions of 5-LOX and AA were carried out at different relative viscosities in Tris buffer (25mM, pH 8.0) at 2

• Telomerase action at the telomere

  2025-03-01

  

  Telomerase action at the telomere is highly regulated; it preferentially elongates the shortest telomeres, and recruitment of the enzyme complex to the telomere occurs in mid-S phase of the cell cycle (Bianchi and Shore, 2007, Britt-Compton et al., 2009, Teixeira et al., 2004, Hemann et al., 2001, T

• Hepatoid adenocarcinoma closely resembles HCC and in some ca

  2025-03-01

  

  Hepatoid adenocarcinoma closely resembles HCC and in some cases can be indistinguishable morphologically. Hepatoid adenocarcinoma is an aggressive neoplasm, and metastasis to the liver is common [12]. Gastric metastasis from HCC has also been reported [27]. Distinguishing hepatoid adenocarcinoma fro

• br The pathogenesis of AD and the targets of

  2025-03-01

  

  The pathogenesis of AD and the targets of apelin Alzheimer's drugs Conclusions Introduction APJ, first identified from a human genomic library in 1993, belongs to a member of seven trans-membrane G protein-coupled receptor family. Its amino XMU-MP-1 sequence has 31% homology with that o

• It has been proven that genetic polymorphisms can play an

  2025-03-01

  

  It has been proven that genetic polymorphisms can play an important role in development of hypertension and CVDs. In a Turkish population-based study, it was found that the APLNR gene (rs948847-A445C) polymorphism was not associated with coronary artery disease (CAD), but it was shown to be related

• br Results A total of respondents

  2025-03-01

  

  Results A total of 126 respondents completed the survey (68.5% response rate), with at least 65% response rate from each of the four represented sectors (denominators represent the total constituent body of the organization or the total attendees of the meeting): PUC 24 out of 37 (65%), SPUNZA 33

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