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Some family I DNA ligases can
2019-07-30
Some family I DNA ligases can use dATP as nucleotide cofactor. For instance, human Clozapine for I uses dATP with a catalytic efficiency that is only 36-fold lower in comparison to ATP [9]. EhDNAlig is unable to use dATP as a nucleotide cofactor, indicating a more constrained active site in compari
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br Introduction Benzanthrone BNZ is a dye
2019-07-30
Introduction Benzanthrone (BNZ) is a dye intermediate used in the synthesis of number of polycyclic vat and disperse dyes. It has been detected as an environmental pollutant in urban ambient air particulates, originating from furnace effluents, municipal refuge, wood and coal combustion and autom
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The protein levels of the
2019-07-30
The protein levels of the three enzymes in the organs in the three earthworm species ranked body wall > intestine > seminal receptacle ≈ seminal vesicle (Fig. 3B).The presence of significant detoxification capability in the body wall would be logically expected in a soil dwelling organism, to facili
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Recently a sandwich cultured hepatocyte model
2019-07-30
Recently, a sandwich-cultured hepatocyte model has been proved to be a valuable in vitro system that maintains specific hepatic cytomorphology and function relevant to drug metabolism, disposition and toxicity, and thus, closely resembles the in vivo setting. This hepatocyte model was recognized as
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The development of C S mutation has been reported in
2019-07-29
The development of C797S mutation has been reported in vivo in a small cohort (15 subjects) of EGFR T790M positive patients progressing after Osimertinib: this tertiary mutation was found, using a droplet digital PCR (ddPCR) assay, in 40% of patients after AR to this agent, while 33% of the cases ex
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In the present study we
2019-07-29
In the present study, we implemented the dendritic RCA-induced formation of amplifying DNAzyme catalytic labels strategy for sensitive and accurate assay of MTase activity and the detection of DNA methylation. In comparison with the traditional RCA process, the proposed strategy achieved high amplif
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br DGKs inhibition and signaling Local DAG
2019-07-29
DGKs inhibition and signaling Local DAG levels are strictly controlled by a balance between synthesis and degradation rates. Both receptor controlled PLC-mediated production and DGK-mediated degradation are classically implicated in the control of “signaling” DAG. However, this dogma is starting
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Studies carried out with LTRAs before the
2019-07-29
Studies carried out with LTRAs before the identification of the CysLT2R, showed a controversial picture, as results that suggest a role for cysteinyl-LTs in the expansion of ischemic damage and in cardiac dysfunction during reperfusion [5], [68], [69] were evenly balanced by others suggesting that t
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Introduction Cytochrome P CYP A is
2019-07-29
Introduction Cytochrome P450 (CYP)3A is the most important enzyme involved in the metabolism of 30–40% of currently prescribed drugs [1]. The nor-NOHA acetate level and activity of CYP3A show large intra- and inter-individual variability, which contributes to unpredictable drug response and toxici
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Similarly to the chemokine CCL the level
2019-07-29
Similarly to the chemokine CCL-5, the level of the chemokine SDF-1 in the groups of individuals with APD did not differ from its level in the control group. However, a slight increase in the level of this chemokine was recorded in the group of women and men with APD and PTSD as compared with the cor
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br Outcome of COX overexpression Although a causal role
2019-07-29
Outcome of COX-2 overexpression Although a causal role for COX-2 has been proposed, mechanisms by which COX-2 function contributes to the pathogenesis of hyperplastic disease are not well defined. To examine if there is any correlation between COX-2 and p53 protein levels, Kumagai et al. [15] rec
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In S cerevisiae Mek a paralog of
2019-07-29
In S. cerevisiae, Mek1, a paralog of the checkpoint kinase Chk2, mediates cell-cycle arrest in response to meiotic defects (Bailis and Roeder, 2000, Xu et al., 1997). Mek1 is associated with meiotic chromosome axes, where its activation requires interactions with two other axis proteins, Hop1 and Re
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br Results and Discussion br
2019-07-29
Results and Discussion Conclusions Understanding the connections between function and fitness is a primary goal of many biological disciplines including systems biology and molecular evolution. While sound approaches have been developed to understand the connections between function and fitnes
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One of the most frequent gene alterations in MM
2019-07-27
One of the most frequent gene alterations in MM is methylation of the p15 and p16 genes in the 5′ upstream region. P15 and p16 proteins are BLZ945 solubility regulators involved in the inhibition of transition from G1 to S phase. Frequencies of p15 or p16 gene methylation up to 32% and 53%, respec
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MuRF and MuRF in http www apexbt
2019-07-27
MuRF1 and MuRF3 in cooperation with the E2 ubiquitin-conjugating enzymes UbcH5a, -b, and -c were found to mediate degradation of myosin heavy chain β/slow (MHC β/slow) and MHC IIa via UPS, both, in vitro and in vivo [60]. Mice lacking both MuRF1 and MuRF3 developed skeletal muscle myopathy and hyper
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