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Nucleophosmin NPM which also plays a role on the nuclear
2019-07-03
Nucleophosmin (NPM1), which also plays a role on the nuclear export of ribosomal proteins and subunits (Maggi et al., 2008), is also a relevant MYC target, presumably through an interaction with CRM1. Conversely, it has been recently reported that specific SINE compounds reduce the levels of MYC in
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The question remained as to why hCrm was
2019-07-03
The question remained as to why hCrm1 was functional and mCrm1 was not in terms of Rev and HIV mRNA nuclear export, and previously we proposed three possibilities (Elinav et al., 2012). One was that human AS1842856 had a positively acting factor that somehow stabilized the hCrm1 and Rev-RRE complex
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br Methods and materials br Cyclooxygenase COX is the key
2019-07-03
Methods and materials Cyclooxygenase (COX) is the key enzyme required for the conversion of arachidonic CBL0137 hydrochloride structure to prostaglandin, prostacyclins and thromboxanes., , , Two distinct isoforms of COX were initially discovered: COX-1 is a constitutive, housekeeping enzyme tha
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br Conflict of interest statement br Acknowledgement The
2019-07-03
Conflict of interest statement Acknowledgement The research leading to these results has received funding from the European Union Seventh Framework Programme (FP7/2007-2013) under grant agreement n° 278742 (Eurosarc) Introduction Pseudomyogenic hemangioendothelioma/epithelioid sarcoma-like
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br Development of the double strand
2019-07-03
Development of the double strand break repair model for meiotic recombination Meiotic recombination was first described by Frans Alfons Janssens using AZD 6244 in the salamander Batracoseps attenuatus in 1909 [21] and then further elaborated at the genetic level in Drosophila by Thomas H. Morgan
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In addition to the blockade of airway smooth
2019-07-03
In addition to the blockade of airway smooth muscle contractions, CysLT1 receptor antagonists also exerted a potent anti-inflammatory effect at this level. The oral administration of MEN91507, Pranlukast, Montelukast, and Zafirlukast also produced a long-lasting inhibition of leukotriene D4-induced
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Future analysis could consider using fixed effects also with
2019-07-03
Future analysis could consider using fixed effects also with the level set field, , in order to investigate which covariates explain the classification, a feature of the proposed model that we have not yet investigated. Further, multi-type point patterns may also be analyzed with the proposed model
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D-(-)-Salicin molecular Cot MAP K is the sole MAP K that act
2019-07-03
Cot (MAP3K8) is the sole MAP3K that activates the MEK1/2-Erk1/2 following the activation of the TLR/IL-1 receptor superfamily as well as some receptors of the TNF receptor family [8], [9], [10] and mediates the production of chemokines and cytokines in different cell systems [reviewed in [11]]. Thus
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Vinorelbine SPR was used to measure biomolecular kinetic int
2019-07-03
SPR was used to measure biomolecular kinetic interactions between TERRA G-quadruplex and ligand in the present study. SPR is a widely used method, but cannot tell which specific type of interaction happened. Compounds with similar structures probably have similar mechanism of interaction, while comp
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br Development of the double strand break repair model
2019-07-02
Development of the double strand break repair model for meiotic recombination Meiotic recombination was first described by Frans Alfons Janssens using IFN-gamma, murine recombinant in the salamander Batracoseps attenuatus in 1909 [21] and then further elaborated at the genetic level in Drosophil
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br DGAT proteins lipid droplets and cancer
2019-07-02
DGAT proteins, lipid droplets and cancer cells Conclusions and future directions Conflicts of interest Acknowledgements This work was supported by NIH grants GM062887, P01CA097132, and Veterans Affairs Merit Award to LMO. Introduction Bioethanol and biodiesel are regarded as the two
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There is literature precedence for the metabolic
2019-07-02
There is literature precedence for the metabolic activation of the methylene carbons adjacent to the ring oxygen(s) of dioxanes and benzopyrans resulting in ring-opened electrophilic carbonyl species. Based on the potential for this metabolic pathway being operative with , a steric block approach wa
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Imidazo purine diones were another
2019-07-02
1-Imidazo[2,1-]purine-2,4(3,8)-diones were another cluster of compounds identified from the Chembridge screen (). A benzyl group at the R2 position was preferred over a phenyl or 2-phenylpropyl (. and ), and -substitution of the benzyl group increased potency to the nanomolar level ( IC=0.20μM . ).
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Introduction The term myeloproliferative disorders
2019-07-02
Introduction The term “myeloproliferative disorders” was first proposed by William Dameshek in 1951. With the discovery of the Philadelphia chromosome, myeloproliferative disorders were classified into two groups: BCR-ABL positive chronic myeloid leukemia (CML) and BCR-ABL negative chronic myelopro
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nicotinic receptor agonist Proteins that associate to PCNA a
2019-07-02
Proteins that associate to PCNA are characterized by having conserved motifs as the PCNA-interacting protein (PIP) motif [29,30], its variant PIP-like motif [31,32] or the APIM motif (Alk B homologue 2 PCNA interacting motif [33,34]); for instance, p21 contains a PIP motif [30], and DNA polymerases
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